MAIT cells are imprinted by the microbiota in early life and promote tissue repair-Reference-Cited by-同舟云学术

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Published:2019-10-25 Issue:6464 Volume:366 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Constantinides Michael G.¹^ORCID,Link Verena M.¹^ORCID,Tamoutounour Samira¹,Wong Andrea C.²^ORCID,Perez-Chaparro P. Juliana³^ORCID,Han Seong-Ji¹,Chen Y. Erin⁴,Li Kelin⁵^ORCID,Farhat Sepideh⁶,Weckel Antonin⁶^ORCID,Krishnamurthy Siddharth R.¹^ORCID,Vujkovic-Cvijin Ivan¹^ORCID,Linehan Jonathan L.¹^ORCID,Bouladoux Nicolas¹³^ORCID,Merrill E. Dean¹^ORCID,Roy Sobhan⁷^ORCID,Cua Daniel J.⁸,Adams Erin J.⁷^ORCID,Bhandoola Avinash⁹^ORCID,Scharschmidt Tiffany C.⁶,Aubé Jeffrey⁵^ORCID,Fischbach Michael A.⁴^ORCID,Belkaid Yasmine¹³^ORCID

Affiliation:

1. Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.

5. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Department of Dermatology, University of California, San Francisco, CA 94143, USA.

7. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

8. Merck & Co., Merck Research Laboratories, Palo Alto, CA 94304, USA.

9. Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells are absent in germ-free mice, and the mechanisms by which microbiota control MAIT cell development are unknown (see the Perspective by Oh and Unutmaz). Legoux et al. show that, in mice, development of MAIT cells within the thymus is governed by the bacterial product 5-(2-oxopropylideneamino)-6- d -ribitylaminouracil, which rapidly traffics from the mucosa to the thymus, where it is captured by MR1 and presented to developing MAIT cells. Constantinides et al. report that MAIT cell induction only occurs during a limited, early-life window and requires exposure to defined microbes that produce riboflavin derivatives. Continual interactions between MAIT cells and commensals in the skin modulates tissue repair functions. Together, these papers highlight how the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens. Science , this issue p. 494 , p. eaax6624 ; see also p. 419

Funder

National Institutes of Health

Howard Hughes Medical Institute

National Institute of General Medical Sciences

Chan Zuckerberg Biohub

Cancer Research Institute

European Molecular Biology Organization

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary