K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

Author:

Choi Murim1,Scholl Ute I.1,Yue Peng2,Björklund Peyman34,Zhao Bixiao1,Nelson-Williams Carol1,Ji Weizhen1,Cho Yoonsang5,Patel Aniruddh1,Men Clara J.1,Lolis Elias5,Wisgerhof Max V.6,Geller David S.7,Mane Shrikant8,Hellman Per4,Westin Gunnar4,Åkerström Göran4,Wang Wenhui2,Carling Tobias3,Lifton Richard P.1

Affiliation:

1. Departments of Genetics and Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

2. Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA.

3. Department of Surgery, Yale Endocrine Neoplasia Laboratory and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA.

4. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

5. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.

6. Division of Endocrinology, Henry Ford Hospital, Detroit, MI 48202, USA.

7. Section of Nephrology, Yale University School of Medicine, and Department of Medicine, Veterans Affairs Medical Center, West Haven, CT 06516, USA.

8. Yale Center for Genome Analysis, Yale University School of Medicine, West Haven, CT 06516, USA.

Abstract

Potassium channel mutations drive both cell growth and hormone production in an adrenal tumor that causes severe hypertension.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways

2. Glomerulosa cell—a unique sensor of extracellular K+ concentration

3. Control of cell proliferation in the rat adrenal gland in vivo by the renin-angiotensin system;McEwan P. E.;Am. J. Physiol.,1996

4. Angiotensins II and IV stimulate the rat adrenocortical cell proliferation acting via different receptors;Pawlikowski M.;Endocr. Regul.,2001

5. Angiotensin II stimulates both aldosterone secretion and DNA synthesis via type 1 but not type 2 receptors in bovine adrenocortical cells

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