Optogenetic Control of Cardiac Function-Reference-Cited by-同舟云学术

Optogenetic Control of Cardiac Function

Published:2010-11-12 Issue:6006 Volume:330 Page:971-974
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arrenberg Aristides B.¹²,Stainier Didier Y. R.³,Baier Herwig¹,Huisken Jan³⁴

Affiliation:

1. Department of Physiology, University of California, San Francisco, CA 94158, USA.

2. Institute of Biology 1, University of Freiburg, 79104 Freiburg, Germany.

3. Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.

4. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Abstract

A Steady Beat A regular heartbeat depends on steady function of the cardiac pacemaker. The early embryonic heart is neither as steady nor as organized as the mature heart. Arrenberg et al. (p. 971 ) used zebrafish engineered to express light-sensitive proteins to locate and manipulate the function of the cardiac pacemaker. By controlling the activity of small patches of cells with light beams, the authors monitored the development of the young heart, showing how the cardiac pacemaker develops during embryogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Development of the cardiac conduction system

2. Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis

3. Localization of pacemaking activity in early embryonic heart monitored using voltage-sensitive dye

4. Functional and morphological evidence for a ventricular conduction system in zebrafish and Xenopus hearts

5. Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System

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