Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla-Reference-Cited by-全球学者库

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

Published:2017-07-07 Issue:6346 Volume:357 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Furlan Alessandro¹^ORCID,Dyachuk Vyacheslav²³⁴,Kastriti Maria Eleni⁵^ORCID,Calvo-Enrique Laura¹,Abdo Hind¹^ORCID,Hadjab Saida²,Chontorotzea Tatiana⁵,Akkuratova Natalia⁶⁷,Usoskin Dmitry¹^ORCID,Kamenev Dmitry²,Petersen Julian⁵⁸^ORCID,Sunadome Kazunori⁵,Memic Fatima¹,Marklund Ulrika¹,Fried Kaj²,Topilko Piotr⁹,Lallemend Francois²^ORCID,Kharchenko Peter V.¹⁰,Ernfors Patrik¹^ORCID,Adameyko Igor⁵⁸^ORCID

Affiliation:

1. Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.

2. Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.

3. National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia.

4. Department of Nanophotonics and Metamaterials, ITMO University, St. Petersburg 197101, Russia.

5. Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.

6. Skolkovo Institute of Science and Technology, Moscow 143005, Russia.

7. Institute of Translational Biomedicine, Saint Petersburg State University, St. Petersburg 199034, Russia.

8. Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.

9. Institut de Biologie de l’Ecole Normale Supérieure, Ecole Normale Supérieure, INSERM U1024, CNRS UMR 8197, 46 Rue d’Ulm, 75005 Paris, France.

10. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Following the yellow brick road The adrenal glands affect a variety of processes such as stress responses and metabolism. The mature adrenal gland is formed from multiple tissue sources, including cells of neural origin. Furlan et al. traced the origins of these cells. The cells first become Schwann cell precursors and follow along nerves to travel from the dorsal root ganglia of the spine to the adrenal gland. Once there, the cells differentiate into chromaffin cells. The authors used singlecell transcriptomics to reveal the shifts in functional programs during migration, development, and differentiation. Science , this issue p. eaal3753

Funder

Ake Wibergs Stiftelse

Ragnar Soderbergs stiftelse

Swedish Research Council Formas

Karolinska Institutet

RFBR

Swedish Cancer Foundation

Knut och Alice Wallenbergs Stiftelse

NHLBI

Bertil Hållstens Forskningsstiftelse

Swedish Research Council

Russian Science Foundation