Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

Author:

Cazalla Demián1,Yario Therese1,Steitz Joan A.1

Affiliation:

1. Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

Abstract

Herpes Virus MiRNA Modulation Viruses use a number of strategies to manipulate the cells of their host to ensure a successful infection. Herpesvirus saimiri (HVS) generates highly conserved small noncoding RNAs HSUR 1 and HSUR 2 , which modulate expression of a number of proteins in infected primate T cells. Cazalla et al. (p. 1563 ; see the Perspective by Pasquinelli ) observed complementarity between HSUR sequences and the seed regions of three different miRNAs—miR-142-3p, miR-27, and miR-16—and found that these HSURs could bind to the miRNAs. Furthermore, the level of mature miR-27 was modulated by binding to HSUR 1 , which targeted the miRNA for degradation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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