A Stem Cell–Based Approach to Cartilage Repair-Reference-Cited by-全球学者库

A Stem Cell–Based Approach to Cartilage Repair

Published:2012-05-11 Issue:6082 Volume:336 Page:717-721
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Johnson Kristen¹,Zhu Shoutian²,Tremblay Matthew S.¹²,Payette Joshua N.²,Wang Jianing²,Bouchez Laure C.²,Meeusen Shelly¹,Althage Alana¹,Cho Charles Y.¹,Wu Xu³,Schultz Peter G.²

Affiliation:

1. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

2. The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. Massachusetts General Hospital, Cutaneous Biology Research Center, Harvard Medical School, Building 149, 13th Street, Room 3219, Charlestown, MA 02129, USA.

Abstract

Osteoarthritis and Kartogenin Osteoarthritis is characterized by progressive breakdown of articular cartilage and affects over 25 million people in the United States. Mesenchymal stem cells (MSCs), which reside in healthy and diseased joints, are multipotent adult stem cells that are able to differentiate into a variety of cell types. Johnson et al. (p. 717 , published online 5 April) identified a small molecule, kartogenin, which was able to induce MSCs to differentiate into chondrocytes in vitro. When administered locally, kartogenin was efficacious in two animal models of osteoarthritis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

2. Pharmacologic therapy for osteoarthritis—the era of disease modification

3. Bone Marrow Mesenchymal Stem Cells: Historical Overview and Concepts

4. Multilineage Potential of Adult Human Mesenchymal Stem Cells

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