Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy-Reference-Cited by-全球学者库

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

Published:1997-11-14 Issue:5341 Volume:278 Page:1295-1300
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Finzi Diana¹²³⁴⁵,Hermankova Monika¹²³⁴⁵,Pierson Theodore¹²³⁴⁵,Carruth Lucy M.¹²³⁴⁵,Buck Christopher¹²³⁴⁵,Chaisson Richard E.¹²³⁴⁵,Quinn Thomas C.¹²³⁴⁵,Chadwick Karen¹²³⁴⁵,Margolick Joseph¹²³⁴⁵,Brookmeyer Ronald¹²³⁴⁵,Gallant Joel¹²³⁴⁵,Markowitz Martin¹²³⁴⁵,Ho David D.¹²³⁴⁵,Richman Douglas D.¹²³⁴⁵,Siliciano Robert F.¹²³⁴⁵

Affiliation:

1. D. Finzi, M. Hermankova, T. Pierson, L. M. Carruth, C. Buck, R. E. Chaisson, T. C. Quinn, J. Gallant, R. F. Siliciano, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. K. Chadwick and J. Margolick, Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.

3. R. Brookmeyer, Department of Biostatistics, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.

4. M. Markowitz and D. D. Ho, Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA.

5. D. D. Richman, Departments of Medicine and Pathology, University of California San Diego, La Jolla CA 92093, USA.

Abstract

The hypothesis that quiescent CD4 + T lymphocytes carrying proviral DNA provide a reservoir for human immunodeficiency virus–type 1 (HIV-1) in patients on highly active antiretroviral therapy (HAART) was examined. In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4 + T lymphocytes. The frequency of resting CD4 + T cells harboring latent HIV-1 was low, 0.2 to 16.4 per 10 6 cells, and, in cross-sectional analysis, did not decrease with increasing time on therapy. The recovered viruses generally did not show mutations associated with resistance to the relevant antiretroviral drugs. This reservoir of nonevolving latent virus in resting CD4 + T cells should be considered in deciding whether to terminate treatment in patients who respond to HAART.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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