Cerebrospinal fluid influx drives acute ischemic tissue swelling-Reference-Cited by-同舟云学术

Cerebrospinal fluid influx drives acute ischemic tissue swelling

Published:2020-03-13 Issue:6483 Volume:367 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mestre Humberto¹²^ORCID,Du Ting¹³^ORCID,Sweeney Amanda M.¹,Liu Guojun¹⁴^ORCID,Samson Andrew J.⁵^ORCID,Peng Weiguo⁵,Mortensen Kristian Nygaard⁵^ORCID,Stæger Frederik Filip⁵^ORCID,Bork Peter A. R.⁵⁶^ORCID,Bashford Logan⁷^ORCID,Toro Edna R.⁷,Tithof Jeffrey⁷^ORCID,Kelley Douglas H.⁷^ORCID,Thomas John H.⁷,Hjorth Poul G.⁶,Martens Erik A.⁶^ORCID,Mehta Rupal I.¹²⁸⁹,Solis Orestes²^ORCID,Blinder Pablo¹⁰¹¹^ORCID,Kleinfeld David¹²¹³^ORCID,Hirase Hajime⁵¹⁴^ORCID,Mori Yuki⁵^ORCID,Nedergaard Maiken¹⁵^ORCID

Affiliation:

1. Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.

3. School of Pharmacy, China Medical University, Shenyang 110122, China.

4. Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.

5. Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

6. Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.

7. Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.

8. Department of Pathology, Rush University, Chicago, IL 60612, USA.

9. Rush Alzheimer’s Disease Center, Rush University, Chicago, IL 60612, USA.

10. Neurobiology, Biochemistry and Biophysics School, George S. Wise Faculty of Life Sciences, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.

11. Sagol School for Neuroscience, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.

12. Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.

13. Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.

14. Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Abstract

Spreading edema after stroke The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Army Research Office

Horizon 2020 Framework Programme

Fondation Leducq

Lundbeckfonden

Novo Nordisk Fonden

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary