Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent-Reference-Cited by-同舟云学术

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

Published:2017-03-31 Issue:6332 Volume:355 Page:1423-1427
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kamphorst Alice O.¹^ORCID,Wieland Andreas¹^ORCID,Nasti Tahseen¹^ORCID,Yang Shu¹²^ORCID,Zhang Ruan³,Barber Daniel L.¹⁴,Konieczny Bogumila T.¹,Daugherty Candace Z.¹,Koenig Lydia⁵,Yu Ke⁵,Sica Gabriel L.⁶,Sharpe Arlene H.⁷^ORCID,Freeman Gordon J.⁸^ORCID,Blazar Bruce R.⁹^ORCID,Turka Laurence A.³,Owonikoko Taofeek K.⁵,Pillai Rathi N.⁵,Ramalingam Suresh S.⁵,Araki Koichi¹,Ahmed Rafi¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China, 410013.

3. Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02144, USA.

4. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

5. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

6. Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

7. Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Woman’s Hospital, Boston, MA 02115, USA.

8. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

9. Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.

Funder

National Institutes of Health

Merck

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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