α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro-Reference-Cited by-全球学者库

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Published:2010-09-24 Issue:5999 Volume:329 Page:1663-1667
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Burré Jacqueline¹,Sharma Manu¹,Tsetsenis Theodoros¹,Buchman Vladimir²,Etherton Mark R.¹,Südhof Thomas C.¹³

Affiliation:

1. Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304–5543, USA.

2. School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

3. Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304–5543, USA.

Abstract

α-Synuclein and Aging Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple αβγ-synuclein knockout mice, and studies of mouse aging, Burré et al. (p. 1663 , published online 26 August) now demonstrate that α-synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals, but becomes essential late in life, which suggests that α-synuclein maintains normal synaptic function during aging.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Mechanisms of membrane fusion: disparate players and common principles

2. Membrane fusion

3. Membrane Fusion: Grappling with SNARE and SM Proteins

4. Presynaptic -Synuclein Aggregates, Not Lewy Bodies, Cause Neurodegeneration in Dementia with Lewy Bodies

5. Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

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