Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span-Reference-Cited by-同舟云学术

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Published:2009-10-02 Issue:5949 Volume:326 Page:140-144
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Selman Colin¹,Tullet Jennifer M. A.²,Wieser Daniela³,Irvine Elaine¹,Lingard Steven J.¹,Choudhury Agharul I.¹,Claret Marc¹,Al-Qassab Hind¹,Carmignac Danielle⁴,Ramadani Faruk⁵,Woods Angela⁶,Robinson Iain C. A.⁴,Schuster Eugene³,Batterham Rachel L.¹,Kozma Sara C.⁷,Thomas George⁷,Carling David⁶,Okkenhaug Klaus⁵,Thornton Janet M.³,Partridge Linda²,Gems David²,Withers Dominic J.¹⁸

Affiliation:

1. Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK.

2. Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.

3. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

4. Division of Molecular Neuroendocrinology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK.

5. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.

6. Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Imperial College, London W12 0NN, UK.

7. Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA.

8. Metabolic Signaling Group, Medical Research Council Clinical Sciences Centre, Imperial College, London W12 0NN, UK.

Abstract

Mimicking Caloric Restriction The extended life span and resistance to age-related diseases in animals exposed to caloric restriction has focused attention on the biochemical mechanisms that produce these effects. Selman et al. (p. 140 ; see the Perspective by

Kaeberlein and Kapahi )

explored the role of the mammalian ribosomal protein S6 kinase 1 (S6K1), which regulates protein translation and cellular energy metabolism. Female knockout mice lacking expression of S6K1 showed characteristics of animals exposed to caloric restriction, including improved health and increased longevity. The beneficial effects included reduced fat mass in spite of increased food intake. Thus, inhibition of signaling pathways activated by S6K1 might prove beneficial in protecting against age-related disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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