Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress-Reference-Cited by-同舟云学术

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

Published:1997-09-12 Issue:5332 Volume:277 Page:1659-1662
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Liu Dong¹²,Diorio Josie¹²,Tannenbaum Beth¹²,Caldji Christian¹²,Francis Darlene¹²,Freedman Alison¹²,Sharma Shakti¹²,Pearson Deborah¹²,Plotsky Paul M.¹²,Meaney Michael J.¹²

Affiliation:

1. D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.

2. P. M. Plotsky, Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA 30322, USA.

Abstract

Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r 's > −0.6). These findings suggest that maternal behavior serves to “program” hypothalamic-pituitary-adrenal responses to stress in the offspring.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference72 articles.

1. Infantile Experience and Resistance to Physiological Stress

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5. The handling procedure involves removing the mother and then rat pups from their cage placing the pups together in a small container and returning the animals 15 min later to their cage and their mothers. The manipulation is generally performed daily for the first 21 days of life. Handling does not represent a period of maternal deprivation because over the course of the day mothers are routinely off their nests and away from pups for periods of 20 to 25 min. At the same time the artificial and nonspecific nature of the handling paradigm is unsettling [

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