Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma-Reference-Cited by-同舟云学术

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

Published:2010-10-08 Issue:6001 Volume:330 Page:228-231
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jones Siân¹,Wang Tian-Li²,Shih Ie-Ming³,Mao Tsui-Lien⁴,Nakayama Kentaro⁵,Roden Richard³,Glas Ruth⁶,Slamon Dennis⁶,Diaz Luis A.¹,Vogelstein Bert¹,Kinzler Kenneth W.¹,Velculescu Victor E.¹,Papadopoulos Nickolas¹

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

2. Department of Gynecology and Obstetrics and Oncology, Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

3. Department of Pathology, Oncology, Gynecology, and Obstetrics, Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

4. Department of Pathology, National Taiwan University College of Medicine, Taipei 100, Taiwan.

5. Department of Gynecology and Obstetrics, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan.

6. Division of Hematology/Oncology, David Geffen School of Medicine at the University of California, Los Angeles, CA 99095, USA.

Abstract

Remodeling Gone Awry The identification of genes that are mutated at high frequency in human tumors can provide important clues to the molecular pathways that drive tumor growth, which in turn can potentially lead to more effective therapies. Jones et al. (p. 228 , published online 9 September; see the cover) looked for such mutations in ovarian clear cell carcinoma, a rare but particularly lethal form of ovarian cancer. Of 42 tumors examined, 57% were found to harbor inactivating mutations in ARID1A , a gene coding for a subunit of the SWI/SNF chromatin remodeling complex, which functions as a master regulator of transcription factor action and gene expression. Thus, proteins associated with the epigenetic control of gene expression can contribute to the development of human cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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