Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex-Reference-Cited by-同舟云学术

Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

Published:2016-03-25 Issue:6280 Volume:351 Page:1443-1446
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Telley Ludovic¹²,Govindan Subashika¹²,Prados Julien¹²,Stevant Isabelle³²,Nef Serge³²,Dermitzakis Emmanouil³⁴⁵²,Dayer Alexandre¹⁶²,Jabaudon Denis¹⁷²

Affiliation:

1. Department of Basic Neurosciences, University of Geneva, Switzerland.

2. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Switzerland.

3. Department of Genetic Medicine and Development, University of Geneva, Switzerland.

4. Biomedical Research Foundation Academy of Athens, Greece.

5. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Saudi Arabia.

6. Department of Psychiatry, Geneva University Hospital, Switzerland.

7. Clinic of Neurology, Geneva University Hospital, Switzerland.

Abstract

Tracking neuronal transcriptional programs Early in brain development, cortical neurons are born near the ventricles, then migrate to their functional destinations. Telley et al. used a fluorescent labeling technique to see what transcripts characterize these earliest stages of neural development. Waves of transcriptional programs are initiated, then passed by as the neuron progresses from proliferative to migratory and finally to connectivity phases. Science , this issue p. 1443

Funder

Synapsis Foundation

Brain and Behavior Foundation

Swiss SystemsX Interdisciplinary

Swiss National Science Foundation

National Center of Competence in Research (NCCR)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq