Local connectivity and synaptic dynamics in mouse and human neocortex-Reference-Cited by-同舟云学术

Local connectivity and synaptic dynamics in mouse and human neocortex

Published:2022-03-11 Issue:6585 Volume:375 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Campagnola Luke¹^ORCID,Seeman Stephanie C.¹^ORCID,Chartrand Thomas¹^ORCID,Kim Lisa¹^ORCID,Hoggarth Alex¹^ORCID,Gamlin Clare¹^ORCID,Ito Shinya¹^ORCID,Trinh Jessica¹^ORCID,Davoudian Pasha¹^ORCID,Radaelli Cristina¹,Kim Mean-Hwan¹^ORCID,Hage Travis¹^ORCID,Braun Thomas²^ORCID,Alfiler Lauren¹^ORCID,Andrade Julia¹,Bohn Phillip¹^ORCID,Dalley Rachel¹^ORCID,Henry Alex¹,Kebede Sara¹^ORCID,Alice Mukora¹^ORCID,Sandman David¹^ORCID,Williams Grace¹^ORCID,Larsen Rachael¹^ORCID,Teeter Corinne¹^ORCID,Daigle Tanya L.¹^ORCID,Berry Kyla¹^ORCID,Dotson Nadia¹^ORCID,Enstrom Rachel¹^ORCID,Gorham Melissa¹^ORCID,Hupp Madie¹^ORCID,Dingman Lee Samuel¹,Ngo Kiet¹,Nicovich Philip R.¹^ORCID,Potekhina Lydia¹^ORCID,Ransford Shea¹^ORCID,Gary Amanda¹^ORCID,Goldy Jeff¹^ORCID,McMillen Delissa¹^ORCID,Pham Trangthanh¹^ORCID,Tieu Michael¹,Siverts La’Akea¹^ORCID,Walker Miranda¹^ORCID,Farrell Colin¹^ORCID,Schroedter Martin¹^ORCID,Slaughterbeck Cliff¹^ORCID,Cobb Charles³^ORCID,Ellenbogen Richard⁴,Gwinn Ryder P.⁵^ORCID,Keene C. Dirk⁶^ORCID,Ko Andrew L.⁴⁷^ORCID,Ojemann Jeffrey G.⁴⁷,Silbergeld Daniel L.⁴,Carey Daniel¹^ORCID,Casper Tamara¹^ORCID,Crichton Kirsten¹^ORCID,Clark Michael¹,Dee Nick¹^ORCID,Ellingwood Lauren¹,Gloe Jessica¹^ORCID,Kroll Matthew¹,Sulc Josef¹^ORCID,Tung Herman¹^ORCID,Wadhwani Katherine¹^ORCID,Brouner Krissy¹^ORCID,Egdorf Tom¹^ORCID,Maxwell Michelle¹,McGraw Medea¹^ORCID,Pom Christina Alice¹^ORCID,Ruiz Augustin¹^ORCID,Bomben Jasmine¹^ORCID,Feng David¹^ORCID,Hejazinia Nika¹^ORCID,Shi Shu¹,Szafer Aaron¹^ORCID,Wakeman Wayne¹^ORCID,Phillips John¹^ORCID,Bernard Amy¹^ORCID,Esposito Luke¹^ORCID,D’Orazi Florence D.¹^ORCID,Sunkin Susan¹^ORCID,Smith Kimberly¹^ORCID,Tasic Bosiljka¹^ORCID,Arkhipov Anton¹^ORCID,Sorensen Staci¹,Lein Ed¹^ORCID,Koch Christof¹^ORCID,Murphy Gabe¹,Zeng Hongkui¹^ORCID,Jarsky Tim¹^ORCID

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA, USA.

2. Byte Physics, Berlin, Germany.

3. The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, USA.

4. Department of Neurological Surgery, University of Washington, Seattle, WA, USA.

5. Epilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience Institute, Seattle, WA, USA.

6. Department of Pathology, University of Washington, Seattle, WA, USA.

7. Regional Epilepsy Center at Harborview Medical Center, Seattle, WA, USA.

Abstract

We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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