Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway-Reference-Cited by-同舟云学术

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

Published:2014-01-31 Issue:6170 Volume:343 Page:533-536
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bolcun-Filas Ewelina¹,Rinaldi Vera D.¹,White Michelle E.¹,Schimenti John C.¹

Affiliation:

1. Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA.

Abstract

Eggs Well Done Germ cells can endure extensive DNA damage during their development. Programmed meiotic double-strand breaks (DSBs) are essential for proper segregation of chromosomes to oocytes and sperm. However, incomplete DSB repair by recombination activates a checkpoint that triggers cell death. Exogenous DNA damage is also lethal to oocytes via a highly sensitive checkpoint. Bolcun-Filas et al. (p. 533 ) show that the CHK2 kinase is a key component of both checkpoints in mouse oocytes. Deletion of Chk2 restored fertility to females that would otherwise be sterile because of a meiotic recombination mutation or radiation exposure.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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