Evidence for a neural law of effect-Reference-Cited by-同舟云学术

Evidence for a neural law of effect

Published:2018-03-02 Issue:6379 Volume:359 Page:1024-1029
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Athalye Vivek R.¹²^ORCID,Santos Fernando J.¹^ORCID,Carmena Jose M.²³⁴^ORCID,Costa Rui M.¹⁵^ORCID

Affiliation:

1. Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.

2. Department of Electrical Engineering and Computer Sciences, University of California–Berkeley, Berkeley, CA 94720, USA.

3. Helen Wills Neuroscience Institute, University of California–Berkeley, Berkeley, CA 94720, USA.

4. Joint Graduate Group in Bioengineering University of California–Berkeley and University of California–San Francisco, Berkeley, CA 94720, USA.

5. Departments of Neuroscience and Neurology, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA.

Abstract

How to select and shape neural activity When we learn a new skill or task, our movements are reinforced and shaped. Learning occurs because the neural activity patterns in the movement control–related brain regions that are rewarded are repeated. But how does this reinforcement work? Athalye et al. developed a closed-loop self-stimulation paradigm in which a target motor cortical activity pattern resulted in the optogenetic stimulation of dopaminergic neurons. With training, mice learned to reenter specific neuronal activity patterns, which triggered self-stimulation and shaped their neural activity to be closer to the target pattern. Science , this issue p. 1024

Funder

Howard Hughes Medical Institute

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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