An atlas of the protein-coding genes in the human, pig, and mouse brain-Reference-Cited by-同舟云学术

An atlas of the protein-coding genes in the human, pig, and mouse brain

Published:2020-03-06 Issue:6482 Volume:367 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sjöstedt Evelina¹²^ORCID,Zhong Wen²^ORCID,Fagerberg Linn²^ORCID,Karlsson Max²^ORCID,Mitsios Nicholas¹^ORCID,Adori Csaba¹,Oksvold Per²^ORCID,Edfors Fredrik²^ORCID,Limiszewska Agnieszka¹^ORCID,Hikmet Feria³^ORCID,Huang Jinrong⁴⁵⁶⁷^ORCID,Du Yutao⁵⁸,Lin Lin⁴⁶^ORCID,Dong Zhanying⁴⁵⁶,Yang Ling⁴⁵⁶^ORCID,Liu Xin⁵⁸^ORCID,Jiang Hui⁹,Xu Xun⁵⁸^ORCID,Wang Jian⁵⁸,Yang Huanming⁵⁸^ORCID,Bolund Lars⁴⁵⁶,Mardinoglu Adil²^ORCID,Zhang Cheng²^ORCID,von Feilitzen Kalle²^ORCID,Lindskog Cecilia³^ORCID,Pontén Fredrik³^ORCID,Luo Yonglun⁴⁵⁶^ORCID,Hökfelt Tomas¹,Uhlén Mathias¹²^ORCID,Mulder Jan¹^ORCID

Affiliation:

1. Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

2. Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

3. Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

4. Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5. BGI-Shenzhen, Shenzhen 518083, China.

6. Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

7. Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.

8. China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

9. MGI, BGI-Shenzhen, Shenzhen 518083, China.

Abstract

Mapping the mammalian brain The diverse physiology of the brain is reflected in its complex organization at regional, cellular, and subcellular levels. Sjöstedt et al. combined data—both newly acquired and from other large-scale brain mapping projects—from transcriptomics, single-cell genomics, in situ hybridization, and antibody-based protein profiling to map the molecular profiles in human, pig, and mouse brain. The analysis is consistent with a conserved basic brain architecture during mammalian evolution, but it does show differences in regional gene expression profiles. Science , this issue p. eaay5947

Funder

Familjen Erling-Perssons Stiftelse

Knut och Alice Wallenbergs Stiftelse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Tissue-based map of the human proteome

2. The HPA Tissue Atlas; www.proteinatlas.org/tissue.

3. Genome-wide atlas of gene expression in the adult mouse brain

4. A High-Resolution Spatiotemporal Atlas of Gene Expression of the Developing Mouse Brain

5. An anatomically comprehensive atlas of the adult human brain transcriptome

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