Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism-Reference-Cited by-同舟云学术

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

Published:1998-08-21 Issue:5380 Volume:281 Page:1191-1193
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Munn David H.¹,Zhou Min¹,Attwood John T.¹,Bondarev Igor¹,Conway Simon J.¹,Marshall Brendan¹,Brown Corrie¹,Mellor Andrew L.¹

Affiliation:

1. D. H. Munn, M. Zhou, J. T. Attwood, I. Bondarev, S. J. Conway, B. Marshall, A. L. Mellor, Programs in Molecular Immunology and Developmental Biology, Institute of Molecular Medicine and Genetics, and Department of Pediatrics, Medical College of Georgia (MCG), 1120 15th Street, Augusta, GA 30912, USA. C. Brown, Department of Pathology, University of Georgia, Athens, GA 30602, USA.

Abstract

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell–induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

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