α-Klotho as a Regulator of Calcium Homeostasis-Reference-Cited by-同舟云学术

α-Klotho as a Regulator of Calcium Homeostasis

Published:2007-06-15 Issue:5831 Volume:316 Page:1615-1618
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Imura Akihiro¹²³⁴⁵,Tsuji Yoshihito¹²³⁴⁵,Murata Miyahiko¹²³⁴⁵,Maeda Ryota¹²³⁴⁵,Kubota Koji¹²³⁴⁵,Iwano Akiko¹²³⁴⁵,Obuse Chikashi¹²³⁴⁵,Togashi Kazuya¹²³⁴⁵,Tominaga Makoto¹²³⁴⁵,Kita Naoko¹²³⁴⁵,Tomiyama Ken-ichi¹²³⁴⁵,Iijima Junko¹²³⁴⁵,Nabeshima Yoko¹²³⁴⁵,Fujioka Makio¹²³⁴⁵,Asato Ryo¹²³⁴⁵,Tanaka Shinzo¹²³⁴⁵,Kojima Ken¹²³⁴⁵,Ito Juichi¹²³⁴⁵,Nozaki Kazuhiko¹²³⁴⁵,Hashimoto Nobuo¹²³⁴⁵,Ito Tetsufumi¹²³⁴⁵,Nishio Takeshi¹²³⁴⁵,Uchiyama Takashi¹²³⁴⁵,Fujimori Toshihiko¹²³⁴⁵,Nabeshima Yo-ichi¹²³⁴⁵

Affiliation:

1. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

2. Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

3. Integrative Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

4. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

5. Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Abstract

α -klotho was identified as a gene associated with premature aging–like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) and provide evidence for an increase of abundance of Na + ,K + -ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca 2+ ] e ) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na + ,K + -ATPase–dependent manner. The increased Na + gradient created by Na + ,K + -ATPase activity might drive the transepithelial transport of Ca 2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Mutation of the mouse klotho gene leads to a syndrome resembling ageing

2. Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein

3. Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho

4. Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

5. Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression

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