The Genomic Landscapes of Human Breast and Colorectal Cancers-Reference-Cited by-同舟云学术

The Genomic Landscapes of Human Breast and Colorectal Cancers

Published:2007-11-16 Issue:5853 Volume:318 Page:1108-1113
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wood Laura D.¹²³⁴⁵,Parsons D. Williams¹²³⁴⁵,Jones Siân¹²³⁴⁵,Lin Jimmy¹²³⁴⁵,Sjöblom Tobias¹²³⁴⁵,Leary Rebecca J.¹²³⁴⁵,Shen Dong¹²³⁴⁵,Boca Simina M.¹²³⁴⁵,Barber Thomas¹²³⁴⁵,Ptak Janine¹²³⁴⁵,Silliman Natalie¹²³⁴⁵,Szabo Steve¹²³⁴⁵,Dezso Zoltan¹²³⁴⁵,Ustyanksky Vadim¹²³⁴⁵,Nikolskaya Tatiana¹²³⁴⁵,Nikolsky Yuri¹²³⁴⁵,Karchin Rachel¹²³⁴⁵,Wilson Paul A.¹²³⁴⁵,Kaminker Joshua S.¹²³⁴⁵,Zhang Zemin¹²³⁴⁵,Croshaw Randal¹²³⁴⁵,Willis Joseph¹²³⁴⁵,Dawson Dawn¹²³⁴⁵,Shipitsin Michail¹²³⁴⁵,Willson James K. V.¹²³⁴⁵,Sukumar Saraswati¹²³⁴⁵,Polyak Kornelia¹²³⁴⁵,Park Ben Ho¹²³⁴⁵,Pethiyagoda Charit L.¹²³⁴⁵,Pant P. V. Krishna¹²³⁴⁵,Ballinger Dennis G.¹²³⁴⁵,Sparks Andrew B.¹²³⁴⁵,Hartigan James¹²³⁴⁵,Smith Douglas R.¹²³⁴⁵,Suh Erick¹²³⁴⁵,Papadopoulos Nickolas¹²³⁴⁵,Buckhaults Phillip¹²³⁴⁵,Markowitz Sanford D.¹²³⁴⁵,Parmigiani Giovanni¹²³⁴⁵,Kinzler Kenneth W.¹²³⁴⁵,Velculescu Victor E.¹²³⁴⁵,Vogelstein Bert¹²³⁴⁵

Affiliation:

1. The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

2. Department of Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

3. GeneGo, St. Joseph, MI 49085, USA.

4. Vavilov Institute of General Genetics, Moscow, Russia.

5. Department of Biomedical Engineering, Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Cancer genes and the pathways they control

2. A census of human cancer genes

3. Mutational analysis of gene families in human cancer

4. Patterns of somatic mutation in human cancer genomes

5. The Consensus Coding Sequences of Human Breast and Colorectal Cancers

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