Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior-Reference-Cited by-全球学者库

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Published:2013-06-07 Issue:6137 Volume:340 Page:1234-1239
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ahmari Susanne E.¹²³⁴,Spellman Timothy⁵,Douglass Neria L.¹²,Kheirbek Mazen A.¹²,Simpson H. Blair¹³⁴,Deisseroth Karl⁶,Gordon Joshua A.¹²,Hen René¹²

Affiliation:

1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

2. Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.

3. Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.

4. Anxiety Disorders Clinic and OCD Research Program, New York State Psychiatric Institute, New York, NY 10032, USA.

5. Department of Physiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

6. Departments of Psychiatry and Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

What Causes Obsessive Compulsive Disorder? Obsessive compulsive disorder is a severe, chronic mental illness that affects millions of individuals. However, the mechanisms underlying this disease are still largely unknown (see the Perspective by Rauch and Carlezon Jr. ). Ahmari et al. (p. 1234 ) stimulated glutamatergic pathways between the orbitofrontal cortex and the ventromedial striatum and used grooming to assess obsessive compulsive behavior in mice. Repetitive stimulation over days triggered changes in the neuronal responses of the ventromedial striatum. Over time, the behavior of the animals became independent of stimulation and could be prevented by the antidepressant fluoxetine. Burguière et al. (p. 1243 ) investigated the neural basis of obsessive compulsive symptoms in a mutant mouse that showed excessive expression of a conditioned form of grooming.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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