Rewiring of Genetic Networks in Response to DNA Damage-Reference-Cited by-同舟云学术

Rewiring of Genetic Networks in Response to DNA Damage

Published:2010-12-03 Issue:6009 Volume:330 Page:1385-1389
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bandyopadhyay Sourav¹,Mehta Monika²,Kuo Dwight³,Sung Min-Kyung⁴,Chuang Ryan³,Jaehnig Eric J.⁵,Bodenmiller Bernd⁶,Licon Katherine¹,Copeland Wilbert³,Shales Michael⁷,Fiedler Dorothea⁷⁸,Dutkowski Janusz¹,Guénolé Aude⁹,van Attikum Haico⁹,Shokat Kevan M.⁷⁸,Kolodner Richard D.¹⁵¹⁰,Huh Won-Ki⁴,Aebersold Ruedi⁶,Keogh Michael-Christopher²,Krogan Nevan J.⁷,Ideker Trey¹³¹⁰

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

2. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

3. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

4. School of Biological Sciences and Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, 151-742 Seoul, Republic of Korea.

5. Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

6. Institute of Molecular Systems Biology, ETH Zürich, Zürich CH 8093, Switzerland, and Faculty of Science, University of Zürich, Zürich CH 8057, Switzerland.

7. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.

8. Howard Hughes Medical Institute, San Francisco, CA 94158, USA.

9. Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands.

10. The Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

DNA Damage Pathways Revealed Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al. (p. 1385 ; see the Perspective by

Friedman and Schuldiner

) report a comparison of large genetic interactomes measured among all yeast kinases, phosphatases, and transcription factors, as the cell responded to DNA damage. The interactomes revealed were highly dynamic structures that changed dramatically with changing conditions. These dynamic interactions reveal genetic relationships that can be more effective than classical “static” interactions (for example, synthetic lethals and epistasis maps) in identifying pathways of interest.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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2. The Genetic Landscape of a Cell

3. A DNA Integrity Network in the Yeast Saccharomyces cerevisiae

4. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

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