Intercontinental Spread of Pyrimethamine-Resistant Malaria-Reference-Cited by-同舟云学术

Intercontinental Spread of Pyrimethamine-Resistant Malaria

Published:2004-08-20 Issue:5687 Volume:305 Page:1124-1124
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Roper Cally¹²³⁴,Pearce Richard¹²³⁴,Nair Shalini¹²³⁴,Sharp Brian¹²³⁴,Nosten François¹²³⁴,Anderson Tim¹²³⁴

Affiliation:

1. London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

2. Southwest Foundation for Biomedical Research, San Antonio, TX, USA.

3. Medical Research Council, Durban, South Africa.

4. Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.

Abstract

Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference11 articles.

1. Mutations inPlasmodium falciparumDihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine‐Sulfadoxine Use and Resistance

2. A Selective Sweep Driven by Pyrimethamine Treatment in Southeast Asian Malaria Parasites

3. Origin and Dissemination ofPlasmodium falciparumDrug‐Resistance Mutations in South America

4. Antifolate antimalarial resistance in southeast Africa: a population-based analysis

5. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

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