Activation of PPARγ Coactivator-1 Through Transcription Factor Docking-Reference-Cited by-同舟云学术

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

Published:1999-11-12 Issue:5443 Volume:286 Page:1368-1371
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Puigserver Pere¹,Adelmant Guillaume¹,Wu Zhidan¹,Fan Melina¹,Xu Jianming²,O'Malley Bert²,Spiegelman Bruce M.¹

Affiliation:

1. Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Cell Biology, Baylor College of Medicine, Houston, TX 77040, USA.

Abstract

Transcriptional coactivators have been viewed as constitutively active components, using transcription factors mainly to localize their functions. Here, it is shown that PPARγ coactivator–1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator–1 (SRC-1) and CREB binding protein (CBP)/p300. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. The docking of PGC-1 to peroxisome proliferator-activated receptor γ (PPARγ) stimulates an apparent conformational change in PGC-1 that permits binding of SRC-1 and CBP/p300, resulting in a large increase in transcriptional activity. Thus, transcription factor docking switches on the activity of a coactivator protein.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Coactivator and corepressor complexes in nuclear receptor function

2. and references therein.

3. Fondell J. D., Guermah M., Malik S., Roeder R. G., Proc. Natl. Acad. Sci. U.S.A. 96, 1959 (1999);

4. Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

5. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

Cited by 521 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cardiac maturation;Journal of Molecular and Cellular Cardiology;2024-02

2. Combined inhibition of surface CD51 and γ-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma;Journal of Hepatology;2023-12

3. Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases;Signal Transduction and Targeted Therapy;2023-11-13

4. Molecular pharmacology of mineralocorticoid receptor antagonists: The role of co-regulators;Steroids;2023-11

5. Effect of Tea Polyphenols, α-Lipoic Acid and Their Joint Use on the Antioxidant and Lipid Metabolism Performance of Hybrid Grouper (♀Epinephelus fuscoguttatus × ♂E. lanceolatu) Fed with High-Lipid Diets;Aquaculture Nutrition;2023-10-30