Common Kibra Alleles Are Associated with Human Memory Performance-Reference-Cited by-同舟云学术

Common Kibra Alleles Are Associated with Human Memory Performance

Published:2006-10-20 Issue:5798 Volume:314 Page:475-478
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Papassotiropoulos Andreas¹²³⁴⁵,Stephan Dietrich A.¹²³⁴⁵,Huentelman Matthew J.¹²³⁴⁵,Hoerndli Frederic J.¹²³⁴⁵,Craig David W.¹²³⁴⁵,Pearson John V.¹²³⁴⁵,Huynh Kim-Dung¹²³⁴⁵,Brunner Fabienne¹²³⁴⁵,Corneveaux Jason¹²³⁴⁵,Osborne David¹²³⁴⁵,Wollmer M. Axel¹²³⁴⁵,Aerni Amanda¹²³⁴⁵,Coluccia Daniel¹²³⁴⁵,Hänggi Jürgen¹²³⁴⁵,Mondadori Christian R. A.¹²³⁴⁵,Buchmann Andreas¹²³⁴⁵,Reiman Eric M.¹²³⁴⁵,Caselli Richard J.¹²³⁴⁵,Henke Katharina¹²³⁴⁵,de Quervain Dominique J.-F.¹²³⁴⁵

Affiliation:

1. Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland.

2. Center for Integrative Human Physiology, University of Zurich, Zurich 8057, Switzerland.

3. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

4. Department of Psychology, Mayo Clinic, Scottsdale, AZ 85259, USA.

5. Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA.

Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele–dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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