Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis-Reference-Cited by-同舟云学术

Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis

Published:2003-03-28 Issue:5615 Volume:299 Page:2071-2074
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Paulsen I. T.¹²,Banerjei L.¹,Myers G. S. A.¹,Nelson K. E.¹,Seshadri R.¹,Read T. D.¹,Fouts D. E.¹,Eisen J. A.¹²,Gill S. R.¹,Heidelberg J. F.¹,Tettelin H.¹,Dodson R. J.¹,Umayam L.¹,Brinkac L.¹,Beanan M.¹,Daugherty S.¹,DeBoy R. T.¹,Durkin S.¹,Kolonay J.¹,Madupu R.¹,Nelson W.¹,Vamathevan J.¹,Tran B.¹,Upton J.¹,Hansen T.¹,Shetty J.¹,Khouri H.¹,Utterback T.¹,Radune D.¹,Ketchum K. A.¹,Dougherty B. A.¹,Fraser C. M.¹³

Affiliation:

1. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

2. Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218, USA.

3. The George Washington University School of Medicine, Departments of Pharmacology and Microbiology and Tropical Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.

Abstract

The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

1. Enterococci

2. Enterococcus, an Emerging Pathogen

3. Multiple-Drug Resistant Enterococci: The Nature of the Problem and an Agenda for the Future

4. CDC Morb. Mortal. Wkly. Rep. 51 902 (2002).

5. Materials and methods are available as supporting material on Science Online.

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