Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy-Reference-Cited by-同舟云学术

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Published:2019-11-15 Issue:6467 Volume:366 Page:881-886
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gil-Cruz Cristina¹^ORCID,Perez-Shibayama Christian¹,De Martin Angelina¹,Ronchi Francesca²,van der Borght Katrien³,Niederer Rebekka¹,Onder Lucas¹,Lütge Mechthild¹^ORCID,Novkovic Mario¹^ORCID,Nindl Veronika¹,Ramos Gustavo⁴⁵^ORCID,Arnoldini Markus⁶,Slack Emma M.C.⁶^ORCID,Boivin-Jahns Valérie⁵⁷^ORCID,Jahns Roland⁵⁸^ORCID,Wyss Madeleine⁹,Mooser Catherine²,Lambrecht Bart N.³,Maeder Micha T.¹⁰,Rickli Hans¹⁰,Flatz Lukas¹,Eriksson Urs¹¹¹²,Geuking Markus B.¹³^ORCID,McCoy Kathy D.⁹^ORCID,Ludewig Burkhard¹^ORCID

Affiliation:

1. Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

2. Maurice Müller Laboratories, Department of Biomedical Research, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Berne, Berne, Switzerland.

3. VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

4. Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.

5. Comprehensive Heart Failure Center, University Hospital of Würzburg, Würzburg, Germany.

6. Institute of Food, Nutrition and Health, ETH, Zurich, Switzerland.

7. Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.

8. Interdisciplinary Bank of Biomaterials and Data Würzburg (IBDW), University Hospital of Würzburg, Würzburg, Germany.

9. Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

10. Cardiology Division, Kantonsspital St. Gallen, St. Gallen, Switzerland.

11. Center for Molecular Cardiology University of Zurich, Zurich, Switzerland.

12. Department of Medicine, GZO Regional Health Center, Wetzikon, Switzerland.

13. Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Abstract

Peptide mimicry breaks the heart Myocarditis, a prolonged chronic inflammation of heart muscle, can eventually progress to inflammatory cardiomyopathy, a serious condition associated with heart failure. Activated T helper (T H ) cells that recognize myosin heavy chain 6–derived peptides are thought to play a central role in this pathogenesis. Using a mouse model of myocarditis, Gil-Cruz et al. found that cardiac myosin–reactive T H cells are initially primed by myosin-peptide mimics derived from commensal Bacteroides species in the gut (see the Perspective by Epelman). Unlike heathy controls, human myocarditis patients also showed detectable immune reactivity to both Bacteroides and cardiac myosin antigens. Treatment with antibiotics dampened inflammatory responses and prevented lethal heart disease. Science , this issue p. 881 ; see also p. 806

Funder

Swiss National Science Foundation

Bundesministerium für Bildung und Forschung

Interdisciplinary Centre for Clinical Research, Universität of Würzburg, Germany

Interdisciplinary Centre for Clinical Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

1. Myocarditis and cardiomyopathy

2. Dilated cardiomyopathy