Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension-Reference-Cited by-全球学者库

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

Published:2007-03-02 Issue:5816 Volume:315 Page:1243-1249
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Curtis Maurice A.¹²³⁴⁵,Kam Monica¹²³⁴⁵,Nannmark Ulf¹²³⁴⁵,Anderson Michelle F.¹²³⁴⁵,Axell Mathilda Zetterstrom¹²³⁴⁵,Wikkelso Carsten¹²³⁴⁵,Holtås Stig¹²³⁴⁵,van Roon-Mom Willeke M. C.¹²³⁴⁵,Björk-Eriksson Thomas¹²³⁴⁵,Nordborg Claes¹²³⁴⁵,Frisén Jonas¹²³⁴⁵,Dragunow Michael¹²³⁴⁵,Faull Richard L. M.¹²³⁴⁵,Eriksson Peter S.¹²³⁴⁵

Affiliation:

1. Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

2. Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.

3. Institute of Biomedicine at Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.

4. Department of Radiology, Bruna Stråket 11 plan 2, Sahlgrenska University Hospital, SE 413 45 Göteborg, Sweden.

5. Department of Oncology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.

Abstract

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2′-deoxyuridine and become mature neurons in the OB.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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