Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

Author:

Narita Masako1,Young Andrew R. J.1,Arakawa Satoko2,Samarajiwa Shamith A.13,Nakashima Takayuki1,Yoshida Sei4,Hong Sungki4,Berry Lorraine S.1,Reichelt Stefanie1,Ferreira Manuela1,Tavaré Simon13,Inoki Ken4,Shimizu Shigeomi2,Narita Masashi1

Affiliation:

1. Cancer Research UK Cambridge Research Institute (CRI), Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

2. Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

3. Department of Oncology, University of Cambridge, Cambridge CB2 0RE, UK.

4. Life Sciences Institute, Department of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

Abstract

A cellular compartment allows simultaneous protein synthesis and degradation.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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