β-cell–mimetic designer cells provide closed-loop glycemic control-Reference-Cited by-同舟云学术

β-cell–mimetic designer cells provide closed-loop glycemic control

Published:2016-12-09 Issue:6317 Volume:354 Page:1296-1301
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xie Mingqi¹,Ye Haifeng²,Wang Hui¹,Charpin-El Hamri Ghislaine³,Lormeau Claude¹⁴,Saxena Pratik¹,Stelling Jörg¹⁴,Fussenegger Martin¹⁵

Affiliation:

1. Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

2. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, 200241 Shanghai, China.

3. Institut Universitaire de Technologie, IUT, Département Génie Biologique, F-69622 Villeurbanne Cedex, France.

4. SIB–Swiss Institute of Bioinformatics, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.

5. University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 Basel, Switzerland.

Abstract

Engineering cells to regulate glucose Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can lead to many serious disorders, including cardiovascular disease and renal failure. Xie et al. engineered a synthetic circuit into human cells that can sense the glucose concentration and respond to correct deregulation. Implants containing designer cells improved glucose regulation in diabetic mice. Science , this issue p. 1296

Funder

European Research Council

Natural Science Foundation of China

National Centre of Competence in Research Molecular Systems Engineering

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options

2. Lifetime risk of diabetes mellitus — how high?

3. The Past 200 Years in Diabetes