Host-Gut Microbiota Metabolic Interactions-Reference-Cited by-同舟云学术

Host-Gut Microbiota Metabolic Interactions

Published:2012-06-08 Issue:6086 Volume:336 Page:1262-1267
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nicholson Jeremy K.¹,Holmes Elaine¹,Kinross James¹,Burcelin Remy²,Gibson Glenn³,Jia Wei⁴,Pettersson Sven⁵

Affiliation:

1. Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

2. Institut National de la Santé et de la Recherche Médicale, U1048, and Institut des Maladies Métaboliques et Cardiovasculaire I2MC, Rangueil Hospital, BP84225, 31432 Toulouse, France.

3. Department of Food and Nutritional Sciences, The University of Reading, Whiteknights, Reading, UK.

4. Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.

5. Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm 117 77, Sweden, and School of Biological Sciences and National Cancer Centre, 11 Hospital Drive, Singapore 169610.

Abstract

The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference69 articles.

1. Honor Thy Gut Symbionts Redux

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