Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome-Reference-Cited by-全球学者库

Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

Published:2003-05-30 Issue:5624 Volume:300 Page:1394-1399
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rota Paul A.¹²³⁴,Oberste M. Steven¹²³⁴,Monroe Stephan S.¹²³⁴,Nix W. Allan¹²³⁴,Campagnoli Ray¹²³⁴,Icenogle Joseph P.¹²³⁴,Peñaranda Silvia¹²³⁴,Bankamp Bettina¹²³⁴,Maher Kaija¹²³⁴,Chen Min-hsin¹²³⁴,Tong Suxiong¹²³⁴,Tamin Azaibi¹²³⁴,Lowe Luis¹²³⁴,Frace Michael¹²³⁴,DeRisi Joseph L.¹²³⁴,Chen Qi¹²³⁴,Wang David¹²³⁴,Erdman Dean D.¹²³⁴,Peret Teresa C. T.¹²³⁴,Burns Cara¹²³⁴,Ksiazek Thomas G.¹²³⁴,Rollin Pierre E.¹²³⁴,Sanchez Anthony¹²³⁴,Liffick Stephanie¹²³⁴,Holloway Brian¹²³⁴,Limor Josef¹²³⁴,McCaustland Karen¹²³⁴,Olsen-Rasmussen Melissa¹²³⁴,Fouchier Ron¹²³⁴,Günther Stephan¹²³⁴,Osterhaus Albert D. M. E.¹²³⁴,Drosten Christian¹²³⁴,Pallansch Mark A.¹²³⁴,Anderson Larry J.¹²³⁴,Bellini William J.¹²³⁴

Affiliation:

1. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

2. Departments of Biochemistry and Biophysics, University of California–San Francisco, San Francisco, CA 94143, USA.

3. Department of Virology, Erasmus University, Rotterdam, 3000 DR, Netherlands.

4. Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to anyof the previouslycharacterized coronaviruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. S. M. Poutanen et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

2. N. Lee et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

3. K. W. Tsang et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

4. Centers for Disease Control and Prevention, Morb. Mortal. Wkly. Rep.52, 357 (2003).

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