A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions-Reference-Cited by-全球学者库

A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions

Published:2021-08-20 Issue:6557 Volume:373 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Desai Ravi V.¹²^ORCID,Chen Xinyue¹^ORCID,Martin Benjamin¹³^ORCID,Chaturvedi Sonali¹,Hwang Dong Woo⁴^ORCID,Li Weihan⁴^ORCID,Yu Chen⁵,Ding Sheng⁵⁶^ORCID,Thomson Matt⁷^ORCID,Singer Robert H.⁴,Coleman Robert A.⁴,Hansen Maike M. K.³^ORCID,Weinberger Leor S.¹⁸⁹^ORCID

Affiliation:

1. Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.

2. Medical Scientist Training Program and Tetrad Graduate Program, University of California, San Francisco, CA 94158, USA.

3. Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, the Netherlands.

4. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

5. Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

6. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.

7. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

8. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.

9. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

Abstract

DNA repair amplifies transcriptional noise The potential role of noise, or stochastic variations in rates of gene expression, remains to be elucidated. Desai et al . used screens to identify a compound, 5′-iodo-2–-deoxyuridine (IdU), that increased gene expression noise in mouse embryonic stem cells in culture without changing the overall rate of transcription of most genes. They propose a model by which the thymidine analog IdU promotes binding of the base excision repair protein AP endonuclease to DNA, thereby inducing helical distortion of DNA and modulating transcriptional bursting. Such modulation of noise enhanced reprogramming of the embryonic stem cells. Thus, variation in gene expression noise could influence developmental or disease processes. —LBR

Funder

National Institutes of Health

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference97 articles.

1. Weitere Studien uber das Wärmegleichgewicht unter Gasmolekulen, Sitzungsber. Kais. Akad. Wiss. Wien Math;Boltzmann L.;Naturwiss,1872

2. Über die Reaktionsgeschwindigkeit bei der Inversion von Rohrzucker durch Säuren

3. Picture coding using pseudo-random noise

4. Some Observations on Biological Noise

5. Vibrating insoles and balance control in elderly people

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