Detection and localization of surgically resectable cancers with a multi-analyte blood test-Reference-Cited by-同舟云学术

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Published:2018-02-23 Issue:6378 Volume:359 Page:926-930
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cohen Joshua D.¹²³⁴⁵^ORCID,Li Lu⁶^ORCID,Wang Yuxuan¹²³⁴^ORCID,Thoburn Christopher³^ORCID,Afsari Bahman⁷,Danilova Ludmila⁷^ORCID,Douville Christopher¹²³⁴^ORCID,Javed Ammar A.⁸^ORCID,Wong Fay¹³⁴^ORCID,Mattox Austin¹²³⁴^ORCID,Hruban Ralph H.³⁴⁹,Wolfgang Christopher L.⁸^ORCID,Goggins Michael G.³⁴⁹¹⁰¹¹,Dal Molin Marco⁴,Wang Tian-Li³⁹,Roden Richard³⁹^ORCID,Klein Alison P.³⁴¹²^ORCID,Ptak Janine¹²³⁴^ORCID,Dobbyn Lisa¹³⁴^ORCID,Schaefer Joy¹³⁴^ORCID,Silliman Natalie¹²³⁴^ORCID,Popoli Maria¹³⁴,Vogelstein Joshua T.¹³,Browne James D.¹⁴,Schoen Robert E.¹⁵¹⁶^ORCID,Brand Randall E.¹⁵^ORCID,Tie Jeanne¹⁷¹⁸¹⁹²⁰^ORCID,Gibbs Peter¹⁷¹⁸¹⁹²⁰,Wong Hui-Li¹⁷^ORCID,Mansfield Aaron S.²¹^ORCID,Jen Jin²²^ORCID,Hanash Samir M.²³,Falconi Massimo²⁴,Allen Peter J.²⁵,Zhou Shibin¹³⁴^ORCID,Bettegowda Chetan¹³⁴,Diaz Luis A.¹³⁴^ORCID,Tomasetti Cristian³⁶⁷^ORCID,Kinzler Kenneth W.¹³⁴^ORCID,Vogelstein Bert¹²³⁴^ORCID,Lennon Anne Marie³⁴⁸¹⁰¹¹^ORCID,Papadopoulos Nickolas¹³⁴^ORCID

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

6. Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

7. Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

8. Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

9. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

10. Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

11. Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

12. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

13. Institute for Computational Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

14. Department of Computer Science, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.

15. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.

16. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

17. Division of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.

18. Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, Australia.

19. Department of Medical Oncology, Western Health, Melbourne, VIC 3021, Australia.

20. Department of Medical Oncology, Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia.

21. Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN 55902, USA.

22. Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55902, USA.

23. Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

24. Division of Pancreatic Surgery, Department of Surgery, San Raffaele Scientific Institute Research Hospital, 20132 Milan, Italy.

25. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

SEEK and you may find cancer earlier Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866

Funder

National Institutes of Health

Doris Duke Charitable Foundation

Commonwealth Fund

John Templeton Foundation

Lustgarten Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

Billi and Bernie Marcus Foundation

Mayo Clinic Clinomics Program, Center for Individualized Medicine

Defense Sciences Office, DARPA

Publisher

American Association for the Advancement of Science (AAAS)