Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures-Reference-Cited by-同舟云学术

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Published:2014-04-11 Issue:6180 Volume:344 Page:208-211
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lee Anna Y.¹²,St.Onge Robert P.³,Proctor Michael J.³,Wallace Iain M.¹,Nile Aaron H.⁴,Spagnuolo Paul A.⁵,Jitkova Yulia⁶,Gronda Marcela⁶,Wu Yan⁶,Kim Moshe K.⁷⁸,Cheung-Ong Kahlin¹²,Torres Nikko P.¹⁷,Spear Eric D.⁹,Han Mitchell K. L.¹⁰,Schlecht Ulrich³,Suresh Sundari³,Duby Geoffrey¹¹,Heisler Lawrence E.¹,Surendra Anuradha¹,Fung Eula³,Urbanus Malene L.²,Gebbia Marinella¹,Lissina Elena¹²,Miranda Molly³,Chiang Jennifer H.¹²,Aparicio Ana Maria³,Zeghouf Mahel¹³,Davis Ronald W.³,Cherfils Jacqueline¹³,Boutry Marc¹¹,Kaiser Chris A.⁹,Cummins Carolyn L.¹⁰,Trimble William S.⁷⁸,Brown Grant W.¹⁷,Schimmer Aaron D.⁶,Bankaitis Vytas A.⁴,Nislow Corey¹²¹²,Bader Gary D.¹²,Giaever Guri¹²¹⁰¹²

Affiliation:

1. The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

3. Department of Biochemistry, Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.

4. Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Sciences Center, College Station, TX 77843–1114, USA.

5. School of Pharmacy, University of Waterloo, Kitchener, Ontario N2G 1C5, Canada.

6. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

7. Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

8. Cell Biology Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

9. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

10. Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

11. Institut des Sciences de la Vie, Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.

12. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

13. Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France.

Abstract

Yeasty HIPHOP In order to identify how chemical compounds target genes and affect the physiology of the cell, tests of the perturbations that occur when treated with a range of pharmacological chemicals are required. By examining the haploinsufficiency profiling (HIP) and homozygous profiling (HOP) chemogenomic platforms, Lee et al. (p. 208 ) analyzed the response of yeast to thousands of different small molecules, with genetic, proteomic, and bioinformatic analyses. Over 300 compounds were identified that targeted 121 genes within 45 cellular response signature networks. These networks were used to extrapolate the likely effects of related chemicals, their impact upon genetic pathways, and to identify putative gene functions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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