A G Protein–Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination-Reference-Cited by-同舟云学术

A G Protein–Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

Published:2009-09-11 Issue:5946 Volume:325 Page:1402-1405
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Monk Kelly R.¹,Naylor Stephen G.¹,Glenn Thomas D.¹,Mercurio Sara¹,Perlin Julie R.¹,Dominguez Claudia¹,Moens Cecilia B.²,Talbot William S.¹

Affiliation:

1. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Making Myelin The myelin sheath insulates neurons and facilitates rapid axonal conduction, and its disruption is characteristic of some neurological disorders, such as multiple sclerosis. Axonal signals stimulate Schwann cells to form myelin in peripheral nerves, but the mechanism is not completely known. By characterizing a mutation identified in zebrafish, Monk et al. (p. 1402 ; see the Perspective by

Meijer

) show that Gpr126, a member of the G protein–coupled receptor superfamily, is essential for myelin formation. It appears that Gpr126 acts as a receptor for axonal signals to elevate cAMP levels in Schwann cells and trigger myelination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. The origin and development of glial cells in peripheral nerves

2. SCIP: A glial POU domain gene regulated by cyclic AMP

3. Axons regulate Schwann cell expression of the POU transcription factor SCIP

4. Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells

5. The POU Factor Oct-6 and Schwann Cell Differentiation

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