Structural topology defines protective CD8 + T cell epitopes in the HIV proteome-Reference-Cited by-同舟云学术

Structural topology defines protective CD8 + T cell epitopes in the HIV proteome

Published:2019-05-03 Issue:6439 Volume:364 Page:480-484
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gaiha Gaurav D.¹²^ORCID,Rossin Elizabeth J.³⁴^ORCID,Urbach Jonathan¹^ORCID,Landeros Christian¹^ORCID,Collins David R.¹⁵^ORCID,Nwonu Chioma¹,Muzhingi Itai¹,Anahtar Melis N.¹⁶^ORCID,Waring Olivia M.¹⁷^ORCID,Piechocka-Trocha Alicja¹⁵^ORCID,Waring Michael¹⁵,Worrall Daniel P.¹^ORCID,Ghebremichael Musie S.¹,Newman Ruchi M.¹,Power Karen A.¹,Allen Todd M.¹,Chodosh James⁴^ORCID,Walker Bruce D.¹³⁵⁷^ORCID

Affiliation:

1. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2. Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

3. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

4. Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA 02114, USA.

5. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

6. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in order to infer mutational constraints (see the Perspective by McMichael and Carrington). The authors validated the method on proteins with published functional outcomes and then assessed mutational constraints within the HIV proteome. Highly networked residues strongly associated with immune control of HIV infection and may lead to protective immunogens for pathogens for which there is currently no efficient vaccine. Science , this issue p. 480 ; see also p. 438

Funder

Howard Hughes Medical Institute

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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