Convergent evolution of pain-inducing defensive venom components in spitting cobras-Reference-Cited by-同舟云学术

Convergent evolution of pain-inducing defensive venom components in spitting cobras

Published:2021-01-22 Issue:6527 Volume:371 Page:386-390
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kazandjian T. D.¹^ORCID,Petras D.²³^ORCID,Robinson S. D.⁴⁵^ORCID,van Thiel J.⁶^ORCID,Greene H. W.⁷^ORCID,Arbuckle K.⁸^ORCID,Barlow A.⁹¹⁰,Carter D. A.⁵^ORCID,Wouters R. M.⁶^ORCID,Whiteley G.¹,Wagstaff S. C.¹¹¹^ORCID,Arias A. S.¹²^ORCID,Albulescu L.-O.¹^ORCID,Plettenberg Laing A.¹⁰^ORCID,Hall C.¹⁰^ORCID,Heap A.¹⁰^ORCID,Penrhyn-Lowe S.¹⁰^ORCID,McCabe C. V.¹³,Ainsworth S.¹^ORCID,da Silva R. R.²¹⁴^ORCID,Dorrestein P. C.²^ORCID,Richardson M. K.⁶^ORCID,Gutiérrez J. M.¹²^ORCID,Calvete J. J.¹⁵^ORCID,Harrison R. A.¹^ORCID,Vetter I.⁵¹⁶^ORCID,Undheim E. A. B.⁴⁵¹⁷¹⁸^ORCID,Wüster W.¹⁰^ORCID,Casewell N. R.¹^ORCID

Affiliation:

1. Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

2. Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

3. Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.

4. Centre for Advanced Imaging, University of Queensland, St Lucia, QLD 4072, Australia.

5. Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia.

6. Institute of Biology, University of Leiden, Leiden 2333BE, Netherlands.

7. Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA.

8. Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

9. School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.

10. Molecular Ecology and Fisheries Genetics Laboratory, School of Natural Sciences, Bangor University, Bangor LL57 2UW, UK.

11. Research Computing Unit, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

12. Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.

13. School of Earth Sciences, University of Bristol, Bristol BS8 1RL, UK.

14. Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Molecular Sciences Department, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

15. Evolutionary and Translational Venomics Laboratory, Consejo Superior de Investigaciones Científicas, 46010 Valencia, Spain.

16. School of Pharmacy, University of Queensland, Woolloongabba, QLD 4102, Australia.

17. Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.

18. Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Blindern, 0316 Oslo, Norway.

Abstract

From offense to defense Venom in snakes is largely used to subdue and/or kill prey, and most venoms have clear actions that facilitate death or paralysis. In one group of snakes, however, venom has evolved and shifted from predation to protection. Specifically, in three different lineages of “spitting” snakes, venom is used to deter predators. Kazandjian et al. show that similar adaptions have occurred within these lineages that transform cytotoxic components into a mixture that acts on mammalian sensory neurons and causes pain. The authors argue that increased predation on these lineages led to similar shifts in venom function. Science , this issue p. 386

Funder

National Science Foundation

Wellcome

Medical Research Council

Leverhulme Trust

Royal Society

Australian Research Council

National Health and Medical Research Council

Deutsche Forschungsgemeinschaft

Research Council of Norway

Elizabeth Artin Kazandjian

Sao Paulo Research Foundation