A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging-Reference-Cited by-全球学者库

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Published:2015-06-05 Issue:6239 Volume:348 Page:1160-1163
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Weiqi¹,Li Jingyi²,Suzuki Keiichiro³,Qu Jing⁴,Wang Ping¹,Zhou Junzhi¹,Liu Xiaomeng²,Ren Ruotong¹,Xu Xiuling¹,Ocampo Alejandro³,Yuan Tingting¹,Yang Jiping¹,Li Ying¹,Shi Liang⁵,Guan Dee¹,Pan Huize¹,Duan Shunlei¹,Ding Zhichao¹,Li Mo³,Yi Fei⁶,Bai Ruijun⁴,Wang Yayu⁵,Chen Chang¹,Yang Fuquan¹,Li Xiaoyu⁷,Wang Zimei⁸,Aizawa Emi³,Goebl April³⁹,Soligalla Rupa Devi³,Reddy Pradeep³,Esteban Concepcion Rodriguez³,Tang Fuchou²¹⁰¹¹¹²,Liu Guang-Hui¹⁸¹¹¹³,Belmonte Juan Carlos Izpisua³

Affiliation:

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

2. Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China.

3. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

4. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

5. Diagnosis and Treatment Center for Oral Disease, the 306th Hospital of the PLA, Beijing, China.

6. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. College of Life Sciences, Peking University, Beijing 100871, China.

8. The Center for Anti-aging and Regenerative Medicine, Shenzhen University, Shenzhen 518060, China.

9. Universidad Católica San Antonio de Murcia, Campus de los Jerónimos s/n, 30107 Guadalupe, Murcia, Spain.

10. Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China.

11. Center for Molecular and Translational Medicine (CMTM), Beijing 100101, China.

12. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.

13. Beijing Institute for Brain Disorders, Beijing 100069, China.

Abstract

Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cell lines (see the Perspective by Brunauer and Kennedy). WS-mesenchymal stem cells displayed features characteristic of premature aging, including heterochromatin disorganization. WRN protein thus functions in the maintenance of heterochromatin, and heterochromatin alterations may represent a driving force of human aging. Science , this issue p. 1160 ; see also p. 1093

Funder

National Natural Science Foundation of China

NSFC

China Postdoctoral Science Foundation

Beijing Natural Science Foundation

National Basic Research Program of China

Strategic Priority Research Program of the Chinese Academy of Sciences

National High Technology Research and Development Program of China

Key Research Program of the Chinese Academy of Sciences

Thousand Young Talents program of China

Publisher

American Association for the Advancement of Science (AAAS)