Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae-Reference-Cited by-全球学者库

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

Published:2001-07-20 Issue:5529 Volume:293 Page:498-506
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tettelin Hervé¹,Nelson Karen E.¹,Paulsen Ian T.¹²,Eisen Jonathan A.¹²,Read Timothy D.¹,Peterson Scott¹³,Heidelberg John¹,DeBoy Robert T.¹,Haft Daniel H.¹,Dodson Robert J.¹,Durkin A. Scott¹,Gwinn Michelle¹,Kolonay James F.¹,Nelson William C.¹,Peterson Jeremy D.¹,Umayam Lowell A.¹,White Owen¹,Salzberg Steven L.¹⁴,Lewis Matthew R.¹,Radune Diana¹,Holtzapple Erik¹,Khouri Hoda¹,Wolf Alex M.¹,Utterback Terry R.¹,Hansen Cheryl L.¹,McDonald Lisa A.¹,Feldblyum Tamara V.¹,Angiuoli Samuel¹,Dickinson Tanja¹,Hickey Erin K.¹,Holt Ingeborg E.¹,Loftus Brendan J.¹,Yang Fan¹,Smith Hamilton O.¹,Venter J. Craig¹,Dougherty Brian A.⁵,Morrison Donald A.⁶,Hollingshead Susan K.⁷,Fraser Claire M.¹³

Affiliation:

1. The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.

2. Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218, USA.

3. George Washington University Medical Center, 2300 Eye Street, NW, Washington, DC 20037, USA.

4. Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

5. Bristol-Myers Squibb PRI, 5 Research Parkway, Wallingford, CT 06492, USA.

6. University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA.

7. University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA.

Abstract

The 2,160,837–base pair genome sequence of an isolate of Streptococcus pneumoniae , a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted coding regions; of these, 1440 (64%) were assigned a biological role. Approximately 5% of the genome is composed of insertion sequences that may contribute to genome rearrangements through uptake of foreign DNA. Extracellular enzyme systems for the metabolism of polysaccharides and hexosamines provide a substantial source of carbon and nitrogen for S. pneumoniae and also damage host tissues and facilitate colonization. A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine (GC) Gram-positive species. Several surface-exposed proteins that may serve as potential vaccine candidates were identified. Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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