Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract
Maps of defense arsenals in microbial genomes
To survive the attack of foreign invaders such as viruses and plasmids, bacteria and archaea fight back with immune systems that are usually clustered in “defense islands” in their genomes. Doron
et al.
took advantage of this property to map microbial defense systems systematically (see the Perspective by Kim). Candidate immune systems were then experimentally validated for their activities. Like well-known defense arsenals such as restriction-modification and CRISPR systems, these additional immune systems now require mechanistic investigation and could potentially be engineered into useful molecular tools in the future.
Science
, this issue p.
eaar4120
; see also p.
993
Funder
FP7 Ideas: European Research Council
Israel Science Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
732 articles.
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