Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium-Reference-Cited by-同舟云学术

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

Published:2010-01-22 Issue:5964 Volume:327 Page:466-469
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Volkman Hannah E.¹,Pozos Tamara C.²,Zheng John²,Davis J. Muse³,Rawls John F.⁴⁵,Ramakrishnan Lalita⁶⁷⁸

Affiliation:

1. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA.

2. Department of Pediatrics, University of Washington, Seattle, WA 98155, USA.

3. Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA.

4. Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

5. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Department of Microbiology, University of Washington, Seattle, WA 98155, USA.

7. Department of Medicine, University of Washington, Seattle, WA 98155, USA.

8. Department of Immunology, University of Washington, Seattle, WA 98155, USA.

Abstract

Garnering Information on Granulomas In tuberculosis, the tuberculous granuloma has been viewed traditionally as a host-protective structure that serves to “wall off” mycobacteria. However, recent work in the zebrafish embryo showed that mycobacteria convert the nascent granuloma into a vehicle for bacterial expansion and dissemination. Thus, intercepting granuloma formation could provide a strategy for treating tuberculosis, an urgent public health goal in light of the epidemic of extensively drug-resistant tuberculosis. Now Volkman et al. (p. 466 , published online 10 December; see the Perspective by

Agarwal and Bishai

) present the molecular pathway by which mycobacteria induce granulomas in zebrafish. Inhibition of this pathway attenuates infection by reducing granuloma formation, suggesting a therapeutic target for tuberculosis treatment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Dichotomous Role of the Macrophage in Early Mycobacterium marinum Infection of the Zebrafish

2. Mycobacterium tuberculosis Infects Dendritic Cells with High Frequency and Impairs Their Function In Vivo

3. The granulomatous inflammatory response. A review.;Adams D. O.;Am. J. Pathol.,1976

4. New insights into the function of granulomas in human tuberculosis

5. Tuberculous Granuloma Formation Is Enhanced by a Mycobacterium Virulence Determinant

Cited by 387 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Breaking the Cycle: Matrix Metalloproteinase Inhibitors as an Alternative Approach in Managing Tuberculosis Pathogenesis and Progression;ACS Infectious Diseases;2024-07-22

2. Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas;2024-07-15

3. Cytokeratin expression and distribution pattern of epithelioid macrophages in granulomatous lesions of animals with different pathological forms of bovine paratuberculosis: cytokeratin as a biomarker of resilience.;2024-05-10

4. How Mycobacterium tuberculosis builds a home: Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs;2024-04-21

5. Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ;Advanced Science;2024-04-11