Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Author:

Rogers Thomas F.12ORCID,Zhao Fangzhu134ORCID,Huang Deli1ORCID,Beutler Nathan1ORCID,Burns Alison134,He Wan-ting134ORCID,Limbo Oliver35ORCID,Smith Chloe13ORCID,Song Ge134ORCID,Woehl Jordan35ORCID,Yang Linlin1ORCID,Abbott Robert K.46ORCID,Callaghan Sean134,Garcia Elijah1,Hurtado Jonathan147ORCID,Parren Mara1,Peng Linghang1,Ramirez Sydney6ORCID,Ricketts James1,Ricciardi Michael J.8ORCID,Rawlings Stephen A.2,Wu Nicholas C.9ORCID,Yuan Meng9ORCID,Smith Davey M.2ORCID,Nemazee David1ORCID,Teijaro John R.1ORCID,Voss James E.1ORCID,Wilson Ian A.349ORCID,Andrabi Raiees134,Briney Bryan147ORCID,Landais Elise1345ORCID,Sok Devin1345ORCID,Jardine Joseph G.35ORCID,Burton Dennis R.13410ORCID

Affiliation:

1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

3. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.

5. IAVI, New York, NY 10004, USA.

6. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

7. Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

8. Department of Pathology, George Washington University, Washington, DC 20052, USA.

9. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

10. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.

Funder

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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