Yeast as a Model Organism

Author:

Botstein David1,Chervitz Steven A.1,Cherry Michael1

Affiliation:

1. The authors are in the Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference11 articles.

1. Saccharomyces Genome Database (SGD) at http://genome-www.stanford.edu/Saccharomyces/; Yeast Genome from MIPS (Martinsried Institute for Protein Sequences) at http://speedy.mips.biochem.mpg.de/mips/yeast/; Yeast Protein Database (YPD) at http://www.proteome.com/YPDhome.html; Goffeau A. et al. Science 274 546 (1996).

2. Botstein D., Fink G. R., Science.240, 1439 (1988).

3. Functional homology of mammalian and yeast RAS genes

4. BLASTP analysis were done between all yeast ORF translations and all unique protein sequences in the human mouse rat cow and sheep sequences in GenBank as of 22 July 1997. We used the BLOSUM62 substitution matrix and low-complexity filters seg and xnu. "Unknown function" means that the ORF had no entry in either the Gene_Product or Description fields within its SGD Locus page as of 30 July 1997. For all ORFs 3783 (60.8%) have unknown function by this definition. BLASTP version 2.0a W. Gish unpublished data

5. Altschul S. F. Gish W. Miller W. Myers E. W. Lipman D. J. J. Mol. Biol. 215 403 (1990).

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