A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes-Reference-Cited by-同舟云学术

A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

Published:1997-08-29 Issue:5330 Volume:277 Page:1306-1309
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ortmann Bodo¹²³⁴,Copeman James¹²³⁴,Lehner Paul J.¹²³⁴,Sadasivan Bhanu¹²³⁴,Herberg Jethro A.¹²³⁴,Grandea Andeas G.¹²³⁴,Riddell Stanley R.¹²³⁴,Tampé Robert¹²³⁴,Spies Thomas¹²³⁴,Trowsdale John¹²³⁴,Cresswell Peter¹²³⁴

Affiliation:

1. B. Ortmann, J. Copeman, P. J. Lehner, B. Sadasivan, P. Cresswell, Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA.

2. J. A. Herberg and J. Trowsdale, Human Immunogenetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

3. A. G. Grandea, S. R. Riddell, T. Spies, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104, USA.

4. R. Tampé, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany.

Abstract

Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated with antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene. It is a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Up to four MHC class I–tapasin complexes were found to bind to each TAP molecule. Expression of tapasin in a negative mutant human cell line (220) restored class I–TAP association and normal class I cell surface expression. Tapasin expression also corrected the defective recognition of virus-infected 220 cells by class I–restricted cytotoxic T cells, establishing a critical functional role for tapasin in MHC class I–restricted antigen processing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

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