Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability-Reference-Cited by-同舟云学术

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Published:2020-08-07 Issue:6504 Volume:369 Page:643-650
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brouwer Philip J. M.¹^ORCID,Caniels Tom G.¹^ORCID,van der Straten Karlijn¹²^ORCID,Snitselaar Jonne L.¹,Aldon Yoann¹^ORCID,Bangaru Sandhya³,Torres Jonathan L.³^ORCID,Okba Nisreen M. A.⁴^ORCID,Claireaux Mathieu¹,Kerster Gius¹,Bentlage Arthur E. H.⁵^ORCID,van Haaren Marlies M.¹,Guerra Denise¹^ORCID,Burger Judith A.¹,Schermer Edith E.¹,Verheul Kirsten D.¹,van der Velde Niels⁶,van der Kooi Alex⁶^ORCID,van Schooten Jelle¹^ORCID,van Breemen Mariëlle J.¹,Bijl Tom P. L.¹,Sliepen Kwinten¹^ORCID,Aartse Aafke¹⁷,Derking Ronald¹^ORCID,Bontjer Ilja¹,Kootstra Neeltje A.⁸,Wiersinga W. Joost²^ORCID,Vidarsson Gestur⁵^ORCID,Haagmans Bart L.⁴^ORCID,Ward Andrew B.³^ORCID,de Bree Godelieve J.²^ORCID,Sanders Rogier W.¹⁹^ORCID,van Gils Marit J.¹^ORCID

Affiliation:

1. Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.

2. Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.

3. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GD, Netherlands.

5. Sanquin Research, Department of Experimental Immunohematology, Amsterdam, Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1006AD Amsterdam, Netherlands.

6. IBIS Technologies BV, 7521PR Enschede, Netherlands.

7. Department of Virology, Biomedical Primate Research Centre, 2288GJ Rijswijk, Netherlands.

8. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.

9. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

Abstract

Sites of vulnerability in SARS-CoV-2 Antibodies that neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be an important tool in treating coronavirus disease 2019 (COVID-19). Brouwer et al. isolated 403 monoclonal antibodies from three convalescent COVID-19 patients. They show that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell. A subset of antibodies was able to neutralize the virus. Competition and electron microscopy studies showed that these antibodies target diverse epitopes on the spike, with the two most potent targeting the domain that binds the host receptor. Science , this issue p. 643

Funder

Bill and Melinda Gates Foundation

University of Amsterdam

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Fondation Dormeur, Vaduz

Health Holland

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. An interactive web-based dashboard to track COVID-19 in real time