Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus-Reference-Cited by-同舟云学术

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

Published:1997-01-31 Issue:5300 Volume:275 Page:678-683
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nakano Naoko¹,Rooke Ronald¹,Benoist Christophe¹,Mathis Diane¹

Affiliation:

1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (INSERM, CNRS, Université Louis Pasteur), 1 rue Laurent Fries, 67404 Illkirch, C.U. de Strasbourg, France.

Abstract

The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo—mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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