Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Author:

Geller Leore T.1ORCID,Barzily-Rokni Michal2ORCID,Danino Tal3,Jonas Oliver H.45,Shental Noam6,Nejman Deborah1ORCID,Gavert Nancy1ORCID,Zwang Yaara1,Cooper Zachary A.78ORCID,Shee Kevin2,Thaiss Christoph A.9,Reuben Alexandre8ORCID,Livny Jonathan2ORCID,Avraham Roi10ORCID,Frederick Dennie T.11,Ligorio Matteo12ORCID,Chatman Kelly13ORCID,Johnston Stephen E.2ORCID,Mosher Carrie M.2,Brandis Alexander14,Fuks Garold15,Gurbatri Candice16ORCID,Gopalakrishnan Vancheswaran8ORCID,Kim Michael8ORCID,Hurd Mark W.17ORCID,Katz Matthew8,Fleming Jason8ORCID,Maitra Anirban18ORCID,Smith David A.2ORCID,Skalak Matt3,Bu Jeffrey3ORCID,Michaud Monia19,Trauger Sunia A.13ORCID,Barshack Iris2021,Golan Talia2122,Sandbank Judith21ORCID,Flaherty Keith T.12,Mandinova Anna223ORCID,Garrett Wendy S.21924,Thayer Sarah P.25,Ferrone Cristina R.26,Huttenhower Curtis227ORCID,Bhatia Sangeeta N.228293031ORCID,Gevers Dirk2ORCID,Wargo Jennifer A.78ORCID,Golub Todd R.323334ORCID,Straussman Ravid1ORCID

Affiliation:

1. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

4. Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

5. Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

6. Department of Mathematics and Computer Science, Open University of Israel, Raanana, Israel.

7. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

8. Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

10. Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

11. Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

12. Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

13. Small Molecule Mass Spectrometry Facility, Faculty of Arts and Sciences Division of Science, Harvard University, Cambridge, MA 02138, USA.

14. Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

15. Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.

16. Department of Biomedical Engineering, Columbia University, New York City, NY 10027, USA.

17. Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

18. Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

19. Harvard T. H. Chan School of Public Health, Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Boston, MA 02115, USA.

20. Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.

21. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

22. Department of Oncology, Sheba Medical Center, Ramat Gan, Israel.

23. Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

24. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

25. Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-6345, USA.

26. Pancreas and Biliary Surgery Program, Massachusetts General Hospital, Boston, MA 02114, USA.

27. Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

28. Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.

29. Howard Hughes Medical Institute (HHMI), Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.

30. Division of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

31. Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

32. HHMI, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

33. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

34. Harvard Medical School, Boston, MA 02115, USA.

Abstract

In model systems, bacteria present in human pancreatic tumors confer resistance to the anticancer drug gemcitabine.

Funder

National Cancer Institute

Israel Science Foundation

Moross Integrated Cancer Center

Fabrikant-Morse Families Research Fund for Humanity

Hymen T. Milgrom Trust

Rising Tide Foundation

Dr. Dvora and Haim Teitelbaum Endowment Fund

Tobias and Toni Gottesfeld Scholarship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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