Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis-Reference-Cited by-同舟云学术

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

Published:2021-10-08 Issue:6564 Volume:374 Page:216-224
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pernigoni Nicolò¹²^ORCID,Zagato Elena¹²^ORCID,Calcinotto Arianna¹²^ORCID,Troiani Martina¹²,Mestre Ricardo Pereira³^ORCID,Calì Bianca¹²^ORCID,Attanasio Giuseppe¹²,Troisi Jacopo⁴^ORCID,Minini Mirko¹²^ORCID,Mosole Simone¹²,Revandkar Ajinkya¹²,Pasquini Emiliano¹²,Elia Angela Rita¹²,Bossi Daniela¹²,Rinaldi Andrea¹²^ORCID,Rescigno Pasquale⁵^ORCID,Flohr Penny⁶,Hunt Joanne⁶,Neeb Antje⁶,Buroni Lorenzo⁶,Guo Christina⁶^ORCID,Welti Jonathan⁶,Ferrari Matteo³,Grioni Matteo⁷^ORCID,Gauthier Josée⁸^ORCID,Gharaibeh Raad Z.⁸^ORCID,Palmisano Anna⁹¹⁰^ORCID,Lucchini Gladys Martinetti¹¹,D’Antonio Eugenia³^ORCID,Merler Sara¹²¹³^ORCID,Bolis Marco¹²¹⁴^ORCID,Grassi Fabio¹⁵,Esposito Antonio⁹¹⁰^ORCID,Bellone Matteo⁷^ORCID,Briganti Alberto¹⁶¹⁷,Rescigno Maria¹⁸¹⁹^ORCID,Theurillat Jean-Philippe¹²,Jobin Christian⁸²⁰²¹^ORCID,Gillessen Silke²³^ORCID,de Bono Johann⁶^ORCID,Alimonti Andrea¹²¹²²²^ORCID

Affiliation:

1. Institute of Oncology Research, Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland.

2. Faculty of Biomedical Sciences, Università della Svizzera Italiana, CH-1011 Lugano, Switzerland.

3. Medical Oncology Unit, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.

4. Theoreo Srl, Montecorvino Pugliano, 84090 Salerno, Italy.

5. Candiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Turin, Italy.

6. Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.

7. Cellular Immunology Unit, IRCCS Ospedale San Raffaele, 20100 Milan, Italy.

8. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville, FL, USA.

9. Experimental Imaging Center, San Raffaele Scientific Institute, 20100 Milan, Italy.

10. School of Medicine, University Vita–Salute San Raffaele, Milan, Italy.

11. Clinical Microbiology Unit, Ente Ospedaliero Cantonale, EOC, CH-6500 Bellinzona, Switzerland.

12. Department of Medicine, Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.

13. Section of Oncology, Department of Medicine, University of Verona, 37134 Verona, Italy.

14. Computational Oncology Unit, Department of Oncology, Istituto di Ricerche Farmacologiche “Mario Negri” IRCCS, 20156 Milano, Italy.

15. Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.

16. Division of Oncology, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

17. University Vita–Salute San Raffaele, Milan, Italy.

18. IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.

19. Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy.

20. Department of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA.

21. Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA.

22. Department of Health Sciences and Technology, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.

Abstract

Microbes hijack prostate cancer therapy Androgens such as testosterone and dihydrotestosterone are essential for male reproduction and sexual function. Androgens can also influence the growth of prostate tumor cells, and androgen deprivation therapy (ADT) either by surgical means (castration) or pharmacological approaches (hormone suppression), is the cornerstone of current prostate cancer treatments. Pernigoni et al . found that when the body was deprived of androgens during ADT, the gut microbiome could produce androgens from androgen precursors (see the Perspective by McCulloch and Trinchieri). Gut commensal microbiota in ADT-treated patients or castrated mice produced androgens that were absorbed into the systemic circulation. These microbe-derived androgens appeared to favor the growth of prostate cancer and helped to facilitate development into a castration- or endocrine therapy–resistant state. —PNK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. Mechanisms of resistance in castration-resistant prostate cancer (CRPC);Chandrasekar T.;Transl. Androl. Urol.,2015

2. A new vision of immunity: homeostasis of the superorganism

3. Cancer and the microbiota

4. Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells

5. Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

Cited by 127 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The human microbiome and benign prostatic hyperplasia: Current understandings and clinical implications;Microbiological Research;2024-04

2. Uncovering the impact of sea mud-containing diet on fecal fragmentation and its potential environmental risks in recirculating aquaculture system of Apostichopus japonicus;Journal of Water Process Engineering;2024-02

3. Bibliometric and visual analysis of intestinal flora and immunity;Medicine;2024-01-26

4. Microbiome and Prostate Cancer: Emerging Diagnostic and Therapeutic Opportunities;Pharmaceuticals;2024-01-13

5. The gut microbiota—as an endocrine organ;Steroid Hormone Receptors in Health and Disease;2024